Effect of quetiapine on morphologic manifestations of traumatic inflammation during mechanical impact on the blood-ophthalmic barrier

Samara State Medical University, Ministry of Health Care of the Russian Federation, 89 Chapayevskaya Street, 443099, Samara, Russia

^* Corresponding author: casiopeya13@mail.ru

Abstract

Mechanical trauma of the eye is an example of a limited injury in which systemic changes in the immune system occur. The aim of the study was to investigate the dynamics of morphological manifestations of traumatic inflammation in experimental mechanical trauma of the eye with the inclusion of quercetin in the schemes of experimental therapy. The experiment was conducted on male mongrel rats of six-month age, weighing 220-240 g in the number of 120 animals. All animals were given a penetrating wound of both eyes. Group 1 animals were not treated for mechanical ocular trauma. Group 2 rats received standard therapy for eye injury, group 3 animals received standard therapy with the addition of quercetin injections intraperitoneally, and group 4 animals received quercetin injections only. To obtain macro preparations of the eyeball, adjacent tissues and subsequent preparation of histologic preparations of both eyes, the head of each animal was fixed in a solution of 10% neutral formalin. Histologic sections were examined using the ocular stereometric grid of G.G. Avtandilov. Conclusions: addition of quercetin injections to the standard therapy of eye trauma promotes intensification of reparative processes, reduction of purulent inflammation intensity and phagocytosis in the remote period, increase in the number of immunocompetent cells in the peri-circumferential zones.