Issue |
E3S Web Conf.
Volume 273, 2021
XIV International Scientific and Practical Conference “State and Prospects for the Development of Agribusiness - INTERAGROMASH 2021”
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Article Number | 12029 | |
Number of page(s) | 7 | |
Section | Environmental Education and Training of Ecologists | |
DOI | https://doi.org/10.1051/e3sconf/202127312029 | |
Published online | 22 June 2021 |
The logit model as a way of integral assessment of oxidative stress induced by mechanical eye injury
1 Samara State University of Railway Transport, st. Svobody, 2в, Samara, 443066, Russia
2 I.M. Sechenov First Moscow State Medical University (Sechenov University), st. Trubetskaya, 8, building 2, Moscow, 119991, Russian Federation
3 Private Institution Educational Organization of Higher Education “Medical University “Reaviz”, st. Chapaevskaya, 227, Samara, 443099, Russia
4 Samara State Medical University, st. Chapaevskaya 89, Samara, 443099, Russia
* Corresponding author: casiopeya13@mail.ru
The eyes are exposed to aggressive environmental influences. The blood-ophthalmic barrier is one of the resistance mechanisms serving to protect the body. Mechanical eye trauma violates the integrity of the hematoophthalmic barrier and induces oxidative stress on the background of general inflammatory process with cellular structures disturbances. The aim of our study was to investigate the peculiarities of free radical processes and antioxidant protection of the organism under induced oxidative stress by mechanical eye injury. The experiment was conducted on males of six months of age in an amount of 150. In blood, liver, brain, heart and skeletal muscle tissues we studied the state of enzyme indicators of oxidative stress in the dynamics in intact animals and in rats with violation of the blood-ophthalmic barrier by mechanical eye injury and different types of therapy. Based on the data obtained, we performed an integral assessment of oxidative homeostasis in injured animals using a logistic model. The resulting logistic regression equations allow modifying the redox processes in the body by applying biologically active compounds as additional therapy, but are of more fundamental than practical interest, as they illustrate the interrelationships of lipid peroxidation-antioxidant system enzymes in the tissues under study.
© The Authors, published by EDP Sciences, 2021
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