| Issue |
E3S Web Conf.
Volume 131, 2019
2nd International Conference on Biofilms (ChinaBiofilms 2019)
|
|
|---|---|---|
| Article Number | 01006 | |
| Number of page(s) | 6 | |
| DOI | https://doi.org/10.1051/e3sconf/201913101006 | |
| Published online | 19 November 2019 | |
Chitosan composites nerve conduits
Department of Biomedical engineering, Stevens Institute of Technology, Hoboken, U.S.A.
a Corresponding author: ychen168@stevens.edu
Traumatic nerve defect affected over 200, 00 people in the US. As it affected so many people, autografts as the golden standard solution have their limitations. Nerve conduits is a new method and the materials for conduits establishing contain biological materials, synthetic materials and composite materials. Among these categories, composite conduits appear better regeneration ability. Also, chitosan demonstrated have the ability to help nerve regeneration. Thus, chitosan composite may be a good choice in the future. This article compares six kinds of chitosan composite: Laminin-chitosan-PLGA, Chitosan-Zinc Oxide Nanocomposite, PCL/Chitosan/Verapamil, Chitosan/ hyaluronic acid conduit, Chitosan/simvastatin/Pluronic F-127 hydrogel and Chitin/ Carboxymethyl (CM)-chitosan by conduit structure, establishment method, sciatic functional index (SFI), electrophysiology and histology data. This article concludes that chitosan-drug-drug delivery system showed the best recovery result.
© The Authors, published by EDP Sciences, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.