E3S Web Conf.
Volume 151, 2020The 1st International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2019)
|Number of page(s)||5|
|Published online||14 February 2020|
Antibacterial Activity of Curcuma longa (turmeric), Curcuma zedoaria (zedoary), and Allium sativum (garlic) Nanoparticle Extract on Chicken with Chronic Respiratory Disease Complex: In Vivo Study
Division of Pathology, Department of Clinic, Reproduction, and Pathology, IPB University, Bogor Indonesia
2 Division of Veterinary Pharmacy Department of Clinic, Reproduction, and Pathology, IPB University, Bogor Indonesia
3 Division of Pharmacology, Department of Anatomy, Physiology, and Pharmacology, IPB University, Bogor Indonesia
4 Indonesian Research Center for Veterinary Science, Bogor, Indonesia
5 Center for Post-harvest Agriculture Research and Development, Bogor Indonesia
* Corresponding author: email@example.com.
Previous in vitro studies showed that nanoparticle extract of turmeric, zedoary, and garlic exhibit antibacterial activity against Mycoplasma gallisepticum (M. gallisepticum) which causes chronic respiratory disease (CRD) in chicken. This research aimed to determine the antibacterial activity of nanoparticles of Curcuma longa, Curcuma zedoaria, and Allium sativum extract to CRD infected chicken. In vivo test of antibacterial activity of turmeric, zedoary, and garlic nanoparticle in combination was conducted on chicken infected by M. gallisepticum and Escherichia coli (E.coli). Antibiotic control used was enrofloxacin. As many as 75 chickens were divided into 5 groups containing 15 chickens each. Group one consisted of healthy chickens (positive control); group two consisted of chickens that have been inoculated by bacteria (negative control); group three (treatment) were chickens inoculated by bacterium and given extract nanoparticle combination on day 7 of infection for 7 days; group four (prevention) were chickens inoculated by bacterium and given combination of extract nanoparticles on day 5 before infection for 14 days; group five were chickens inoculated with bacterium and given enrofloxacin antibiotics for 7 days. In vivo research results showed increased body weight and performance indicated by improvements in clinical signs, and gross pathology changes. The combination of three extract nanoparticles showed the best activity in controlling CRD in chicken, both as preventive and curative means.
Key words: chronic respiratory disease / turmeric / wild ginger / garlic
© The Authors, published by EDP Sciences, 2020
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