E3S Web Conf.
Volume 169, 2020Actual Problems of Ecology and Environmental Management: Cooperation for Sustainable Development and Environmental Safety (APEEM 2020)
|Number of page(s)||5|
|Published online||19 May 2020|
About the role of environmental factors in carcinogenesis
Far Eastern State Medical University, Khabarovsk, Russia
2 Peoples’ Friendship University of Russia (RUDN University), Faculty of Ecology, 6 MiklukhoMaklaya St, Moscow, 117198, Russian Federation
* Corresponding author: email@example.com
There were found out the connections of the activity of the Sun and smoke of forest fires with the incidence of various forms of benign and malignant neoplasms in the population of young children 0-4 years old, in Khabarovsk Region, Russia. Thus, it was determined that so-called “sporadic” fluctuations in the incidence of neoplasms in the child population are not random. They are caused by long multi-year cycles of changes in the complex of environmental factors. The authors identified this phenomenon as “Alternative oncogenesis”, meaning by it the predominant occurrence of various forms of neoplasms in a certain period of time due to a change in the parameters of the complex of environmental factors. A proposed hypothesis is: ecologically linked oxidative stress as a cause of the epigenomic modulation leading to an imbalance between semaphorins and integrins that brings to oncogenesis.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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