| Issue |
E3S Web Conf.
Volume 189, 2020
2020 International Conference on Agricultural Science and Technology and Food Engineering (ASTFE 2020)
|
|
|---|---|---|
| Article Number | 02023 | |
| Number of page(s) | 4 | |
| Section | Food Biochemistry and Food Processing | |
| DOI | https://doi.org/10.1051/e3sconf/202018902023 | |
| Published online | 15 September 2020 | |
Supplementation of Rhodomyrtus tomentosa fruit polyphenols improved dextran sulfate induced colitis in mice by regulating gut microbiota
1
School of medicine, Jianghan University, Wuhan, Hubei, China
2
Enshi Center for Disease Control and Prevention, Enshi Tujia and Miao Autonomous Prefecture, Hubei, China
3
Hubei Key Laboratory of Applied Toxicology, Wuhan, Hubei, China
* Corresponding author: yuanfh@jhun.edu.cn
To investigate the therapeutic effect of polyphenol from the fruits of Rhodomyrtus tomentosa (RTFP) on experimental colitis induced by dextran sulphate sodium(DSS) in mice. A total of 24 Babl/c mice were randomly divided into normal control group, colitis model group and DSS+RTFP intervention group, respectively. The intestinal disease activity index (DAI), pathological histology of colon were investigated, and the changes of gut microbiota in mice were evaluated by 16S rRNA sequencing. Compared with the DSS-induced colitis group, RTFP showed intestinal anti-inflammatory effects, the DAI score was significantly decreased, RTFP improved colitis induced weight loss, fecal imformation and blood in the stool. RTFP relieved the phenomenon of shortening colon length, shortening intestinal wall, and splenomegaly. RTFP intervention inhibited the increase of bacteroides abundance caused by DSS, and remodeled the diversity of gut microbiota. Taken together, RTFP could effectively intervene in experimental colitis induced by DSS in mice, which may be related to the modulating gut microbiota and intestinal cell immune balance.
© The Authors, published by EDP Sciences, 2020
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