| Issue |
E3S Web Conf.
Volume 210, 2020
Innovative Technologies in Science and Education (ITSE-2020)
|
|
|---|---|---|
| Article Number | 17004 | |
| Number of page(s) | 7 | |
| Section | Social Determinants and Health Behaviors | |
| DOI | https://doi.org/10.1051/e3sconf/202021017004 | |
| Published online | 04 December 2020 | |
The role of neurochemical factors in the chronic mercury intoxication development
East-Siberian Institute of Medical and Ecological Research, 12a microdistrict, 3, Angarsk, 665827, Russia
* Corresponding author: kudaeva_irina@mail.ru
The search of pathogenetic targets for the diagnosis and treatment of mercury intoxication is an actual problem. The aim of the investigation was to study the dynamics of changes in neurochemical parameters in workers in contact with mercury and in persons in the early and distant period of intoxication. A prospective cohort examination included 69 men, exposed to mercury vapors in the workplace (1) and 36 patients in the distant (2) and 18 – in initial period of chronic mercury intoxication (3). Serotonin, histamine, catecholamines and their metabolites were determined in blood plasma. The maximum number of indicators that changed in the dynamics of the survey was registered in the group 2. Dopamine level increased by a maximum value - 284%, noradrenaline - 124%. Only the noradrenaline content changed in 3.2 times in patients in the group 3 and in 1.4 times in experienced workers without pathology. This changes in experienced workers was partially offset by its transition to inactive metabolite normetanephrine. The increase of noradrenaline concentration was not accompanied by increase of its metabolite level in the group 3. But the increase of the dopamine, serotonin and histamine joined in the distant period of chronic mercury intoxication.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.