E3S Web Conf.
Volume 218, 20202020 International Symposium on Energy, Environmental Science and Engineering (ISEESE 2020)
|Number of page(s)||8|
|Section||Environmental Chemistry and Environmental Pollution Analysis and Control|
|Published online||11 December 2020|
Advances in research on the pathogenesis of depression based on signaling pathways
College of Life Sciences Sichuan University
Depression is an affective disorder that endangers human health, and its main clinical feature is significant and persistent depression. The pathological mechanism of depression is complex and has not been fully elucidated so far. In recent years, with the further study of molecular biology techniques, depression is closely related with mood regulation, cognitive function, function changes of specific protein and abnormal cell signal transduction pathways in the brain, causing cell dysfunction, which affects the brain nerve cells apoptosis regeneration mechanism of trigger depressive symptoms. By referring to and sorting out relevant literatures, this paper comprehensively described the research progress of the signal transduction mechanism of cyclic adenosine phosphate (cAMP), mitogen-activated protein kinase (MAPK) and calmodulin kinase (CaMK) in depression, so as to provide reference for explaining the pathogenesis of depression and developing treatment plans.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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