E3S Web Conf.
Volume 218, 20202020 International Symposium on Energy, Environmental Science and Engineering (ISEESE 2020)
|Number of page(s)||5|
|Section||Environmental Chemistry and Environmental Pollution Analysis and Control|
|Published online||11 December 2020|
Cancer Stem Cell as Target of CAR-T Cell Therapy
Division of Biological Sciences, University of California, San Diego, San Diego, CA, US
* Corresponding author: firstname.lastname@example.org
Chimeric antigen receptor-T cell (CAR-T) therapy has been studied intensively these years and is considered a promising cancer treatment. So far, Food and Drug Administration has approved 2 CAR-T cell therapy for patients with refractory leukemia and the result is positive. However, CAR-T cell therapy is still facing several challenges, including antigen escape, which will diminish the efficacy of treatment and lead to relapse. This review investigates the potential of cancer stem cell (CSC), a small group of cancer cells that contribute to tumorigenesis, metastasis, therapy resistance and relapse, as the target of CAR-T cell therapy, focusing on representative CSC surface markers: CD123, CD133 and CD44. Evidence indicates that CAR-T cell therapy directed by CSC surface markers is effective and feasible. Therefore, CSC targeted CAR-T cell therapy is a prospective treatment for cancer.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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