E3S Web Conf.
Volume 218, 20202020 International Symposium on Energy, Environmental Science and Engineering (ISEESE 2020)
|Number of page(s)||6|
|Section||Environmental Chemistry and Environmental Pollution Analysis and Control|
|Published online||11 December 2020|
Cancer Detection from Plasma Cell-Free DNA
Department of Biomedical Engineering, Engineering College, Peking University, Beijing, China
Liquid biopsy of cell-free DNA (cfDNA) has attracted much attention for its promise to realize pan-cancer detection in a non-invasive way. The whole-genome bisulfite sequencing (WGBS) is widely used in cfDNA sequencing analysis and lays the foundation for further study on cfDNA. The cfDNA released by multiple tissues carries genetic and epigenetic information. Methylation patterns, copy number variation (CNV) and fragmentation changes have been discovered in previous studies and achieved a promising accuracy. In this review, different cancer detection methods based on these three biomarkers are introduced. In addition, feature fusion is discussed for its potential in enhancing performance in clinical applications.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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