Utilization of tekelan leaf extract (Chromolaena odorata L.) based on nanoliposome technology as treatment of antihyperglycemia

Department Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma no 5, Medan, 20155, North Sumatera, Indonesia

^* Corresponding author: rahmisofia10@gmail.com

Abstract

Metabolic disease that occurs due to abnormalities in insulin secretion and insulin action is said to be diabetes or hyperglycemia. One alternative that can be used for hyperglycemia management is to use tekelan leaves (C. odorata L.). The leaves of this tekelan plant have low water solubility and high permeability. A liposome is a good carrier to increase the solubility and penetration of the compounds it carries. This study aimed to develop a nanotechnological liposomal preparation from the ethanol extract of tekelan leaves as a hypoglycemic agent in diabetic male rats induced by nicotinamide 120 mg/kg BW and streptozotocin 60 mg/kg BW. Antihyperglycemia treatment was applied to nanoliposomes at a dose of 25 mg / kg BW, 125 mg / kg BW, 250 mg / kg BW, CMC-Na and 0.45 mg / kg BW of glibenclamide. The results obtained were at 12 ’sonication time, the resulting particle size is 145.5 ± 2.8 and PI 0.307 ± 0.03. The results of antihyperglycemia testing were obtained at a nanoliposome dose of 250 mg/kg BW produced the lowest blood glucose levels, namely, 86 ± 4.30 mg / dL.