| Issue |
E3S Web Conf.
Volume 245, 2021
2021 5th International Conference on Advances in Energy, Environment and Chemical Science (AEECS 2021)
|
|
|---|---|---|
| Article Number | 03027 | |
| Number of page(s) | 10 | |
| Section | Chemical Performance Research and Chemical Industry Technology Research and Development | |
| DOI | https://doi.org/10.1051/e3sconf/202124503027 | |
| Published online | 24 March 2021 | |
Exploring the effects of CDK7 inhibition by YKL-5-124 on the molecular mechanisms and the ways it triggers cytokines production in Small Cell Lung Cancer in vitro
Biochemistry and Molecular Biology; Department of Biological Science; University of California, Davis; Davis, California, 95616, United States
The previous study has researched that combining YKL-5-124, CDK7 specific target drug with anti-PD-1 treatment had a survival advantage in various Small Cell Lung Cancer models. However, the molecular mechanism that YKL-5-124 triggers inflammatory response remains unknown. This study investigates the effects of CDK7 inhibition by YKL-5-124 on two DNA damage pathways (ATM and ATR) of SCLC in vitro. The result of this study will reveal the effects of CDK7 inhibition by YKL-5-124 on the molecular mechanisms of SCLC and potentially promote the development of new anticancer treatment strategies based on immunity manipulation.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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