| Issue |
E3S Web Conf.
Volume 271, 2021
2021 2nd International Academic Conference on Energy Conservation, Environmental Protection and Energy Science (ICEPE 2021)
|
|
|---|---|---|
| Article Number | 02021 | |
| Number of page(s) | 5 | |
| Section | Environmental Protection and Green Application of Energy Saving and Emission Reduction | |
| DOI | https://doi.org/10.1051/e3sconf/202127102021 | |
| Published online | 15 June 2021 | |
The Immune Contexture and Cancer Therapy Aspects of the TIM-3 Checkpoint Pathway
Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States
* Corresponding author's e-mail: ldico930@163.com
The advent of immune checkpoint therapy revolutionizes the oncology field by achieving durable anti-tumor efficacy and immense clinical progress. Among the immune checkpoints, T cell immunoglobulin and mucin domain 3 (TIM-3) has been reported to express on both innate and adaptive immune cells where it accounts for immune tolerance and tumor aggression. It shows promising effects that are applicable in several cancer types. This review provides a broad overview of the main TIM-3 relative signaling pathways and its immune regulatory role to shape cancer development positively. The importance of TIM-3 inhibitors in cancer control were also summarized according to the latest reports, discussing its clinical trial data that inform the rationale for TIM-3 blockade.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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