E3S Web Conf.
Volume 271, 20212021 2nd International Academic Conference on Energy Conservation, Environmental Protection and Energy Science (ICEPE 2021)
|Number of page(s)||9|
|Section||Research on Energy Chemistry and Chemical Simulation Performance|
|Published online||15 June 2021|
Function, Development and Challenges of COVID-19 Diagnostic Methods in Two Areas: RT-PCR Tests and Serology Tests
1 School of Biological Sciences and Biotechnology, Beijing forestry University, No.35 East Qinghua Road, China
2 The Department of Medicine, Soochow university, No. 199, Ren'ai Road, China
The ongoing outbreaks of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic of Coronavirus Disease (COVID-19) in 2019. Nucleic Acid Tests as the current most prevalent method are able to detect the presence of SARS-CoV-2 from infected patients by comparing target viral genome sequences in high sensitivity and accuracy. Three widely applied nucleic acid methods for clinical and research purpose including RT-PCR tests, LAMP and CRISPR-Cas based detection are introduced firstly, followed by the discussion of Antibody Tests, which are ICG and CL immunoassay tests.These two fields of COVID-19 diagnostic methods exhibit some advantages and drawbacks depending on various clinical settings. Antibody test is supplementary and complementary of other diagnostic methods while Nucleic acid tests are overall effectively and rapidly to diagnose infected patients for immediate treatment and isolation. The combination of these two methods may eventually control the dissemination of COVID-19 pandemic.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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