E3S Web Conf.
Volume 271, 20212021 2nd International Academic Conference on Energy Conservation, Environmental Protection and Energy Science (ICEPE 2021)
|Number of page(s)||4|
|Section||Environmental Materials and Solid Waste Recycling Technology|
|Published online||15 June 2021|
Effects of Natural Products on Nonalcoholic Fatty Liver Disease through Nrf2 Epigenetic Regulation
School of Life Science, 999077 Sha Tin, Hong Kong, China
* Corresponding author: firstname.lastname@example.org
Non-alcoholic fatty liver disease has become one of the common illnesses among urban dwellers worldwide. Many consider natural products as better options for medicine and diet supplements. In recent years, researchers found that natural products can prevent human diseases by reactivating silencing genes through epigenetic regulation. They also discovered nuclear factor erythroid-2-related factor-2 (Nrf2) as is an important factor in the response of anti-oxidation has a close relation to lipogenesis. Studies showed with the higher expression of DNA methyl-transferases, the higher methylation of Nrf2 promoter occurred. With the high methylation rate of the Nrf2 promoter, the expression of Nrf2 reduced thus enhanced lipid accumulation, which may cause NAFLD. Furthermore, with lower expression of Nrf2, the downstream antioxidant genes’ expression decreased, which may cause oxidative stress to human body cells. Understanding the pathway of Nrf2 and NAFLD can shed a light on discovering new development of drugs. This paper reviews several natural products and their mechanisms of alleviating NAFLD and hopes to bring in new perspectives on the treatment and the development of new drugs on NAFLD.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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