| Issue |
E3S Web Conf.
Volume 338, 2022
7th International Conference on Environmental Science and Material Application (ESMA 2021)
|
|
|---|---|---|
| Article Number | 01005 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/e3sconf/202233801005 | |
| Published online | 20 January 2022 | |
Synthesis and Characterization of Hydroxyl-Pinacolone Retinoate
Qingdao University of Science and Technology, Qingdao, China
* Corresponding author: aurock@126.com
All-trans retinoic acid (10) was synthesized by β-ionone (5) through knoevenagel condensation, reduction and hydrolysis reaction. Then, hydroxyl-pinacolone retinoate (11) was prepared by the esterification with 1-hydroxy- 3, 3-dimethylbutan-2-ketone. This route not only reduces the synthesis steps but also helps to increase the yield. The structure of the product was characterized by 1H NMR and 13C NMR.
© The Authors, published by EDP Sciences, 2022
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