| Issue |
E3S Web Conf.
Volume 449, 2023
International Scientific and Practical Conference “Priority Directions of Complex Socio-Economic Development of the Region” (PDSED 2023)
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|---|---|---|
| Article Number | 07016 | |
| Number of page(s) | 8 | |
| Section | Innovative, Scientific and Educational Subsystems in the Socio-economic Development of the Region | |
| DOI | https://doi.org/10.1051/e3sconf/202344907016 | |
| Published online | 16 November 2023 | |
Effect of extracellular levanase SacC from Bacillus subtillis on two–species Staphylococcus aureus – Pseudomonas aeruginosa biofilms
Kazan (Volga Region) Federal University, Institute of Fundamental Medicine and Biology, 420008 Kremlevskaya 18, Kazan, Russia
* Corresponding author: trizna91@mail.ru
The formation of polymicrobial biofilms significantly increases the resistance of bacteria in them to a wide range of antibiotics thus making their eradication challenging in infectious medicine. In recent years, the emergence of a large number of antibiotic-resistant strains has contributed to a significant increase in severe cases of infectious diseases. Natural compounds such as alkaloids, terpenes, bacterial peptides and enzymes have great potential in combating polymicrobial diseases, associated with the biofilm formation. At the same time, the enzymatic treatment of biofilms has a number of advantages, since the enzymes are nontoxic, do not cause resistance and can increase the effectiveness of existing antimicrobials. Here we show that recombinant extracellular levanase SacC can promote the destruction of two-species biofilms S. aureus – P. aeruginosa and increase the effectiveness of antibiotics against bacteria in the biofilm up to 16 times.
© The Authors, published by EDP Sciences, 2023
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