Functionalized graphene MOFs in drug delivery application

¹ Department of Chemistry, UIS, Chandigarh University, Gharuan, 140301, Punjab, India
² Chemistry Department, University of New Hampshire, Durham
³ Uttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India
⁴ Department of Refrigeration and Air Conditioning Techniques, College of Technical Engineering, The Islamic University, Najaf, Iraq
⁵ Department of Refrigeration and Air Conditioning Techniques, College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq
⁶ Research & Incubation Centre, Rayat Bahra University, Greater Mohali, Punjab, INDIA – 140103
⁷ School of Pharmaceutical Sciences, Bahra University, Waknaghat, Solan 173234, Himachal Pradesh, India

^* Corresponding author: lalita.e2341@cumail.in

Abstract

The research of the MOFs for biological activities have garnered a lot of interest in current history. Because of their exceptionally wide surfaces, and permeability, Metal-organic framework are thought to be an exciting type of nanocarriers for the dlivery of pharmaceuticals. The unique characteristics of MOFs and their advantages as Nanomaterials for drug administration in therapeutic systemshave been reviewed in the first half of this paper. The most current techniques included hydrophilic group, pore encapsulated, covatent linkin, and using basic components of useful molecules. Strong bonds are used to join inorganic and organic units to create according to the utilization of metal-organic frameworks versality of the elements, structure, dimension, and usefulness, more that twenty thousdand different MOFs have been reported and investigated in the last ten years. An overview, different types of ligands, and numerous techniques for MOF synthesis are given at the beginning of the chapter. In many applications where MOFs are potential options, the special property of MOFs has been a significant problem. The latest scientific applications of MOFs for aptamer- specific intracellular drug, protein, and nucleic acid delivery were discussed. Finally, issues and opportunities were thoroughly covered to set the stage for the evolution of MOFs into an effective drug delivery system in the future.