| Issue |
E3S Web Conf.
Volume 527, 2024
The 4th Edition of Oriental Days for the Environment “Green Lab. Solution for Sustainable Development” (JOE4)
|
|
|---|---|---|
| Article Number | 01023 | |
| Number of page(s) | 7 | |
| Section | Natural & Environmental Resources Management | |
| DOI | https://doi.org/10.1051/e3sconf/202452701023 | |
| Published online | 24 May 2024 | |
The synergistic effect of the combination of Ocimum basilicum and Ceratonia siliqua on inflammation and oxidative stress
1 Laboratory of Life and Health Sciences, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, University Abdelmalek Essaadi, 90000, Tangier, Morocco
2 Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, 60000, Oujda, Morocco
3 Department of Biology, Faculty of Sciences and Technology, University Abdelmalek Essaadi, 90000, Tangier, Morocco
4 Laboratory of Biochemistry, Faculty of Sciences & Techniques, University Moulay Ismail, Morocco
5 Laboratory of Biotechnology, Environment, Agri-Food and Health, Faculty of Sciences Dhar Mahraz, Sidi Ben Abdallah University, Fez, Morocco
* Corresponding author: touissilham@gmail.com
The use of basil and carob in traditional medicine to address inflammation and oxidative stress reflects a long-standing practice rooted in folk medicine. This study was conducted to demonstrate the anti-inflammatory and antioxidant properties of a rosmarinic acid-rich extract of Ocimum basilicum (RAE) combined with a carob aqueous extract (CAE). Paw edema in rats and vascular permeability in mice were measured to investigate the anti-inflammatory effect. The assessment of lipoprotein oxidation was carried out by measuring thiobarbituric acid reactive substances as well as determining the scavenging activity towards lipoperoxyl radicals and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The combination (200 mg/kg) significantly decreased carrageenan-induced rat paw edema and vascular permeability in mice (p<0.001), and these effects were comparable to those of the indomethacin drug (50 mg/kg). Moreover, the combination significantly prevented plasma lipoprotein oxidation and efficiently scavenged lipoperoxyl (IC50= 160 ± 11 μg/ml) and DPPH (IC50= 80 ± 4 μg/ml) radicals. The present study indicates the potential nutraceutical benefits of combining Basil and Carob in the treatment of inflammatory and oxidative stress-related diseases, which is correlated with the high contents of rosmarinic acid, phenolic acids, and fibres.
Key words: Ocimum basilicum / rosmarinic acid / Carob / inflammation / lipid oxidation
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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