Recent discoveries about HIF-1α related mechanism and application

Faculty of Life Sciences and Medicine, King College London, WC2R 2LS London, UK

^* Corresponding author: k21058093@kcl.ac.uk

Abstract

Hypoxia-inducible factor 1-alpha (HIF-1α) plays a pivotal role in a myriad of cellular processes, orchestrating numerous pathways that are intrinsically linked to the progression of cancer. The scientific community has been engrossed in studying HIF-1α for an extended period, with novel findings being unveiled consistently. A significant portion of these investigations delves into understanding the intricate mechanisms underpinning HIF-1α’s function and its potential applications in therapeutic interventions. This article offers a comprehensive overview of some of the most recent scholarly contributions in this domain. Key mechanisms explored include the mitochondrial reactive oxygen species (mROS)/HIF-1α pathway, the influence of mechanical stress on the HIF-1α pathway, the mechanistic target of rapamycin complex 1 (mTORC1)/eukaryotic translation initiation factor 4E (EIF4E) pathway, and the microRNAs-34a (miR- 34a)/glucose transport 1 (GLUT1) pathway. Beyond mechanisms, the article also sheds light on the potential applications of these findings, particularly in the realm of drug development aimed at treating cancer and a spectrum of other diseases. In addition to presenting the core research, this review endeavors to furnish readers with pertinent background information on associated terminologies. While it’s challenging to encapsulate the entirety of recent advancements in a single article, the aim here is to inspire and pave the way for future explorations into the mechanisms and therapeutic applications of HIF-1α.