| Issue |
E3S Web Conf.
Volume 609, 2025
The 7th International Conference on Multidiscipline Approaches for Sustainable Rural Development (ICMA SURE 2024)
|
|
|---|---|---|
| Article Number | 04006 | |
| Number of page(s) | 6 | |
| Section | Health Sciences | |
| DOI | https://doi.org/10.1051/e3sconf/202560904006 | |
| Published online | 24 January 2025 | |
The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells
1 Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, Central Java, Indonesia
2 Graduate School, Universitas Jenderal Soedirman, Purwokerto, Central Java, Indonesia
3 Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, Central Java, Indonesia
4 Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, Central Java, Indonesia
* Corresponding author: dhadhang.kurniawan@unsoed.ac.id
Nephroprotective agents are substances that protect the kidneys from nephrotoxicity. Some nephroprotective agents are derived from medicinal plants. Sambiloto (Andrographis paniculata) is one of the herbal plants known to have a nephroprotective effect. This study aims to determine the nephroprotective potential of chitosan-based ethanol extract nanoparticles of Andrographis paniculata on the Vero cell line. Andrographis paniculata ethanol extract nanoparticles were prepared using ionic gelation. These nanoparticles exhibited a viability percentage ranging from 97.251% to 107.258% at concentrations of 50-1000 ppm. In the acute protective test, Andrographis paniculata ethanol extract nanoparticles at a chitosan-based concentration of 500 ppm showed a protective ability of 3.26%. In the recovery test, they exhibited a recovery ability ranging from 4.35% to 21.01% at concentrations of 100-500 ppm, and in the chronic protection test, the recovery ability ranged from 5.01% to 14.24% at concentrations of 100-500 ppm. Chitosan-based ethanol extract nanoparticles of Andrographis paniculata are non-toxic and have nephroprotective abilities in both recovery and protection tests.
© The Authors, published by EDP Sciences, 2025
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