Ziprasidone Hydrochloride Nanosuspension for Bioavailability Enhancement: Design, Development and Evaluation

¹ Government pharmacy college, Gandhinagar, Government polytechnic campus, K6 circle- 382025, Gujarat, India.
² School of Pharmaceutical Sciences, Atmiya University, Kalawad Road, Rajkot- 360005, Gujarat, India.
³ School of Pharmacy, RK University, Rajkot-Bhavnagar highway, Rajkot- 360020, Gujarat, India.
⁴ Vardhaman College of Engineering, Hyderabad, India

^* Corresponding author: vaibhavi.savalia@rku.ac.in

Abstract

Ziprasidone hydrochloride belongs to BCS Class II since it possesses high membrane permeability along with low solubility properties. Research shows that the full available amount of a 20 mg dose reaches the body system at a rate of 60%.A research study undertakes the development of Ziprasidone Hydrochloride nanosuspension to optimize dissolution characteristics and enhance saturation solubility to boost oral bioavailability. Formation of the nanosuspension started with nanoprecipitation- ultrasonication method before mannitol addition as cryoprotectant for lyophilization. An optimized design was implemented to control both the desired particle dimension and saturation dissolving capacity of the solution.The evaluation of the nanosuspension included tests for dissolution rate alongside zeta potential analysis, saturation solubility examinations, mean particle size determination, morphological investigation (SEM) as well as in vivo bioavailability experiments. The research outcome showed the development of a nanosuspension having a defined particle size range with an average dimension of 220 ± 10 nm and a polydispersity index of 0.456 ± 0.051 while possessing a zeta potential measurement of -32.1 ± 1.45 mV.The nanoparticles from nanoprecipitation showed superior drug dissolution performance and saturation solubility than the commercial formulation and standard drug solution.