Acute Toxicity Test of Pigeon Pea Leaves Extract (Cajanus cajan) in Rats

Tutik Wresdiyati; Stephany Stephany; Ekowati Handharyani; Siti Sa’diah; Made Astawan

doi:10.1051/e3sconf/202015101043

All issues

Volume 151 (2020)

E3S Web Conf., 151 (2020) 01043

References

Open Access

Issue		E3S Web Conf. Volume 151, 2020 The 1^st International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2019)


Article Number		01043
Number of page(s)		4
DOI		https://doi.org/10.1051/e3sconf/202015101043
Published online		14 February 2020

Nahar L, Nasrin F, Zahan R, et al.: Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity. Pharm Res. 2014;6 (2):180–187. [Google Scholar]
Quan M, Liang J: The influences of four types of soil on the growth, physiological, and biochemical characteristics of Lycoris aurea (L’Her.) herb. Sci Rep. 2017;7:43284. [CrossRef] [PubMed] [Google Scholar]
Wresdiyati T, S Sa’diah, M Astawan :The Antioxidant, Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Cajanus cajan Leaves and Zingiber officinale var. Amarum. JAPS, 2019 (under review). [Google Scholar]
Chinedu E, Arome D, Ameh FS: A new method for determining acute toxicity in animal models. Toxic Inter. 2013; 20(3): 224–226. [CrossRef] [Google Scholar]
Jen–Yin G, Richard JW, Libby D, et al. : Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980-2013. Toxicol Res. 2015; 4: 1297–1307. [Google Scholar]
Doke SK, Dhawale SC : Alternatives to animal testing: a review. Saudi Pharm J. 2015;23:223. [Google Scholar]
Saganuwa SA: Toxicity study of drugs and chemicals in animals: an overview. BJVM. 2016; 1311–1477. [Google Scholar]
[OECD423] The Organization for Economic Co-Operation and Development. OECD Guideline for Testing of Chemicals: Acute Oral Toxicity – Acute Toxic Class Method. USA: The Organization for Economic CoOperation and Development. 2001. [Google Scholar]
Hodge A, Sterner B : 2005. Toxicity Classes. https://www.ccohs.ca/oshanswers/chemicals/ld50.html [Google Scholar]
Fitriani U, Dewi TF, Wijayanti E : Analysis of liver function and kidney function in rats after giving Piper retrofractum, Plantago major and Apium graveolens. PROS SEM NAS MASY BIODIV INDON. ISSN: 24078050. 2019; 5(2): 263–266. [Google Scholar]
Roosdiana A, Hendrawan VF, Wulandari M : The rice bran as therapy agent to decrease the SGOT/SGPT activities and improve the Histopathology of liver in white rat (Rattus norvegicus) induced by high cholesterol diet. IOP Conference Series : Materials Science and Engineering. 2019;546. 062026. DOI: 10.1088/1757-899X/546/6/062026. [Google Scholar]
Manns MP, Lohse AW, Vergani D: Autoimmune hepatitis. J Hepatol. 2015;62 (1):S100–S111. [Google Scholar]
Fontana R, Hayashi P : Clinical features, diagnosis, and natural history of drug–induced liver injury. Seminars in Liver Disease. 2014;34 (2):134–144. [CrossRef] [PubMed] [Google Scholar]
David S, Hamilton JP. Drug–induced liver injury. US Gastroenterol Hepatol Rev. 2011;6:73–80. [Google Scholar]
Lammert C, Bjornsson E, Niklasson A, et al. : Oral medications with significant hepatic metabolism at higher risk for hepatic aderse events. Hepatol. 2010;51:615–620. [CrossRef] [Google Scholar]
Fausto N, Campbell JS, Riehle KJ : Liver regeneration. Hepatology, 2006; 43:S45–S53. [CrossRef] [PubMed] [Google Scholar]
Kleiner DE: The histopathological evaluation of druginduced liver injury. Histopathology. 2017; 70(1): 81–93. DOI: 10.1111/his.13082 [Google Scholar]
Kotyk T, Dey N, Ashour AS, et al. : Measurement of the glomerulus diameter and bowman’s space thickness of renal albino rats. Comput Methods Prog Biomed. 2016;126:143–153. [CrossRef] [Google Scholar]
Cachat F, Combescure C, Cauderay M, et al : A systematic review of glomerular hyperfiltration assessment and definition in the medical literature. Clin J Am Soc Nephrol. 2015;10 (3):382–389. [CrossRef] [PubMed] [Google Scholar]
Radhakrishnan J, Mark A, Perazella MA: Drug-Induced Glomerular Disease: Attention Require!. Clin J Am Soc Nephrol. 2015; 10:1287–1290. doi: 10.2215/CJN.01010115. [CrossRef] [PubMed] [Google Scholar]
Bellomo R, Wan L, May C : Vasoactive drugs and acute kidney injury. Crit Care Med. 2008;36:S179–S186. [CrossRef] [PubMed] [Google Scholar]
Tojo A, Kinugasa S: Mechanisms of glomerular albumin filtration and tubular reabsorption. Int J Nephrol. 2012; 481–520. [Google Scholar]
Tojo A, Onozato M, Ha H, et al. : Reduced albumin reabsorption in the proximal tubule of early–stage diabetic rats. Histochem Cell Biol. 2001; 116(3): 269–276. [CrossRef] [PubMed] [Google Scholar]
Lopes JA, Jorge S : The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin Kidney J. 2013; 6(1): 8–14. [Google Scholar]

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[1] Nahar L, Nasrin F, Zahan R, et al.: Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity. Pharm Res. 2014;6 (2):180–187. [Google Scholar]

[2] Quan M, Liang J: The influences of four types of soil on the growth, physiological, and biochemical characteristics of Lycoris aurea (L’Her.) herb. Sci Rep. 2017;7:43284. [CrossRef] [PubMed] [Google Scholar]

[3] Wresdiyati T, S Sa’diah, M Astawan :The Antioxidant, Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Cajanus cajan Leaves and Zingiber officinale var. Amarum. JAPS, 2019 (under review). [Google Scholar]

[4] Chinedu E, Arome D, Ameh FS: A new method for determining acute toxicity in animal models. Toxic Inter. 2013; 20(3): 224–226. [CrossRef] [Google Scholar]

[5] Jen–Yin G, Richard JW, Libby D, et al. : Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980-2013. Toxicol Res. 2015; 4: 1297–1307. [Google Scholar]

[6] Doke SK, Dhawale SC : Alternatives to animal testing: a review. Saudi Pharm J. 2015;23:223. [Google Scholar]

[7] Saganuwa SA: Toxicity study of drugs and chemicals in animals: an overview. BJVM. 2016; 1311–1477. [Google Scholar]

[8] [OECD423] The Organization for Economic Co-Operation and Development. OECD Guideline for Testing of Chemicals: Acute Oral Toxicity – Acute Toxic Class Method. USA: The Organization for Economic CoOperation and Development. 2001. [Google Scholar]

[9] Hodge A, Sterner B : 2005. Toxicity Classes. https://www.ccohs.ca/oshanswers/chemicals/ld50.html [Google Scholar]

[10] Fitriani U, Dewi TF, Wijayanti E : Analysis of liver function and kidney function in rats after giving Piper retrofractum, Plantago major and Apium graveolens. PROS SEM NAS MASY BIODIV INDON. ISSN: 24078050. 2019; 5(2): 263–266. [Google Scholar]

[11] Roosdiana A, Hendrawan VF, Wulandari M : The rice bran as therapy agent to decrease the SGOT/SGPT activities and improve the Histopathology of liver in white rat (Rattus norvegicus) induced by high cholesterol diet. IOP Conference Series : Materials Science and Engineering. 2019;546. 062026. DOI: 10.1088/1757-899X/546/6/062026. [Google Scholar]

[12] Manns MP, Lohse AW, Vergani D: Autoimmune hepatitis. J Hepatol. 2015;62 (1):S100–S111. [Google Scholar]

[13] Fontana R, Hayashi P : Clinical features, diagnosis, and natural history of drug–induced liver injury. Seminars in Liver Disease. 2014;34 (2):134–144. [CrossRef] [PubMed] [Google Scholar]

[14] David S, Hamilton JP. Drug–induced liver injury. US Gastroenterol Hepatol Rev. 2011;6:73–80. [Google Scholar]

[15] Lammert C, Bjornsson E, Niklasson A, et al. : Oral medications with significant hepatic metabolism at higher risk for hepatic aderse events. Hepatol. 2010;51:615–620. [CrossRef] [Google Scholar]

[16] Fausto N, Campbell JS, Riehle KJ : Liver regeneration. Hepatology, 2006; 43:S45–S53. [CrossRef] [PubMed] [Google Scholar]

[17] Kleiner DE: The histopathological evaluation of druginduced liver injury. Histopathology. 2017; 70(1): 81–93. DOI: 10.1111/his.13082 [Google Scholar]

[18] Kotyk T, Dey N, Ashour AS, et al. : Measurement of the glomerulus diameter and bowman’s space thickness of renal albino rats. Comput Methods Prog Biomed. 2016;126:143–153. [CrossRef] [Google Scholar]

[19] Cachat F, Combescure C, Cauderay M, et al : A systematic review of glomerular hyperfiltration assessment and definition in the medical literature. Clin J Am Soc Nephrol. 2015;10 (3):382–389. [CrossRef] [PubMed] [Google Scholar]

[20] Radhakrishnan J, Mark A, Perazella MA: Drug-Induced Glomerular Disease: Attention Require!. Clin J Am Soc Nephrol. 2015; 10:1287–1290. doi: 10.2215/CJN.01010115. [CrossRef] [PubMed] [Google Scholar]

[21] Bellomo R, Wan L, May C : Vasoactive drugs and acute kidney injury. Crit Care Med. 2008;36:S179–S186. [CrossRef] [PubMed] [Google Scholar]

[22] Tojo A, Kinugasa S: Mechanisms of glomerular albumin filtration and tubular reabsorption. Int J Nephrol. 2012; 481–520. [Google Scholar]

[23] Tojo A, Onozato M, Ha H, et al. : Reduced albumin reabsorption in the proximal tubule of early–stage diabetic rats. Histochem Cell Biol. 2001; 116(3): 269–276. [CrossRef] [PubMed] [Google Scholar]

[24] Lopes JA, Jorge S : The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin Kidney J. 2013; 6(1): 8–14. [Google Scholar]