Open Access
E3S Web Conf.
Volume 245, 2021
2021 5th International Conference on Advances in Energy, Environment and Chemical Science (AEECS 2021)
Article Number 03050
Number of page(s) 4
Section Chemical Performance Research and Chemical Industry Technology Research and Development
Published online 24 March 2021
  1. Pereira-Leal JB, Seabra MC. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol. 2000; 301:1077–87. W. Strunk Jr., E.B. White, The Elements of Style, third ed., Macmillan, New York, 1979. [Google Scholar]
  2. Colicelli J. Human RAS superfamily proteins and related GTPases. Sci STKE. 2004; 250:RE13. [PubMed: 15367757] [Google Scholar]
  3. Bhuin T, Roy JK. Rab11 in disease progression. Int J Mol Cell Med. 2015;4(1):1-8. [PubMed] [Google Scholar]
  4. Goldenring JR, Shen KR, Vaughan HD, Modlin IM. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem. 1993 Sep 5;268(25):18419-22. PMID: 8360141. [PubMed] [Google Scholar]
  5. JE, Wang X, Kumar R, Bhartur SG, Navarre J, Woodrum JE, Altschuler Y, Ray GS, Goldenring JR. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 1999; 10:47–61. [PubMed] [Google Scholar]
  6. Fukuda M. Regulation of secretory vesicle traffic by Rab small GTPases. Cell Mol Life Sci. 2008; 65:2801–13. [PubMed] [Google Scholar]
  7. Wang S, Hu C, Wu F, He S. Rab25 GTPase: Functional roles in cancer. Oncotarget. 2017 Jul 26;8(38):64591-64599. doi: 10.18632/oncotarget.19571. PMID: 28969096; PMCID: PMC5610028. [PubMed] [Google Scholar]
  8. Eathiraj S, Pan X, Ritacco C, Lambright DG. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005; 436:415–9. [PubMed] [Google Scholar]
  9. Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol. 2009; 10:513–25. [CrossRef] [PubMed] [Google Scholar]
  10. Haas AK, Yoshimura S, Stephens DJ, Preisinger C, Fuchs E, Barr FA. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci. 2007; 120:2997–3010. [Google Scholar]
  11. Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW, Mills GB. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med. 2004; 10:1251–6. [PubMed] [Google Scholar]
  12. Zhang J, Wei J, Lu J, Tong Z, Liao B, Yu B, Zheng F, Huang X, Chen Z, Fang Y, Li B, Chen W, Xie D, et al. Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling. Carcinogenesis. 2013; 34:2401–8. [PubMed] [Google Scholar]
  13. Geng D, Zhao W, Feng Y, Liu J. Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion. Tumour Biol. 2016; 37:7713–8. [PubMed] [Google Scholar]
  14. Ding B, Cui B, Gao M, Li Z, Xu C, Fan S, He W. Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells. Oncol Res. 2017; 25:331–40. [PubMed] [Google Scholar]
  15. Fan Y, Wang L, Han X, Liu X, Ma H. Rab25 is responsible for phosphoinositide 3-kinase/AKT mediated cisplatin resistance in human epithelial ovarian cancer cells. Mol Med Rep. 2015; 11:2173–8. [PubMed] [Google Scholar]
  16. Wrzeszczynski KO, Varadan V, Byrnes J, Lum E, Kamalakaran S, Levine DA, Dimitrova N, Zhang MQ, Lucito R. Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer. PLoS One. 2011; 6:e28503. [Google Scholar]
  17. Kikuchi M, Yamashita K, Waraya M, Minatani N, Ushiku H, Kojo K, Ema A, Kosaka Y, Katoh H, Sengoku N, Enomoto T, Tanino H, Sawanobori M, et al. Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. Oncotarget. 2016; 7:1741–53. oncotarget.6480. [CrossRef] [PubMed] [Google Scholar]
  18. Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J, Beauchamp RD, Goldenring JR. Transformation of 64599 Oncotarget rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken). 2011; 68:97–111. [CrossRef] [PubMed] [Google Scholar]
  19. Jeong BY, Cho KH, Jeong KJ, et al. Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin [published correction appears in Exp Mol Med. 2018 Sep 19;50(9):124]. Exp Mol Med. 2018;50(1):e435. Published 2018 Jan 26. doi:10.1038/emm.2017.248. [Google Scholar]
  20. Mitra S, Cheng KW, Mills GB. Rab25 in cancer: a brief update. Biochem Soc Trans. 2012; 40:1404–8. [CrossRef] [PubMed] [Google Scholar]
  21. Li, Yuanyuan, et al. “Rab25 Upregulation Correlates with the Proliferation, Migration, and Invasion of Renal Cell Carcinoma.” Biochemical and Biophysical Research Communications, vol. 458, no. 4, 2015, pp. 745–750., doi: 10.1016/j.bbrc.2015.01.144. [CrossRef] [PubMed] [Google Scholar]
  22. Jeong, Haengdueng, et al. “Loss of Rab25 Promotes the Development of Skin Squamous Cell Carcinoma through the Dysregulation of Integrin Trafficking.” The Journal of Pathology, vol. 249, no. 2, 2019, pp. 227–240., doi:10.1002/path.5311. [CrossRef] [PubMed] [Google Scholar]
  23. Gankhuyag N, Yu KN, Davaadamdin O, Lee S, Cho WY, Park C, Jiang HL, Singh B, Chae CH, Cho MH, Cho CS. Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice. J Aerosol Med Pulm Drug Deliv. 2017; 30:81–90. [CrossRef] [PubMed] [Google Scholar]
  24. Zhang X, Lu Y, Shen G, Li J. Effect of RAB25 gene on proliferation of human breast cancer cell line MCF-7 in vivo and in vitro. Int J Clin Exp Pathol. 2016; 9:4746–55. [Google Scholar]
  25. Gomez-Roman N, McGregor F, Wheate NJ, Plumb JA. Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model. J Ovarian Res. 2015; 8:62. [CrossRef] [PubMed] [Google Scholar]
  26. Cao C, Lu C, Xu J, Zhang J, Zhang J, Li M. Expression of Rab25 correlates with the invasion and metastasis of gastric cancer. Chin J Cancer Res. 2013;25(2):192-199. doi: 10.3978/j.issn.1000-9604.2013.03.01 [Google Scholar]
  27. Kessler, Daniel, et al. “The Action of Small GTPases Rab11 and Rab25 in Vesicle Trafficking During Cell Migration.” Cellular Physiology and Biochemistry, vol. 29, no. 5-6, 2012, pp. 647–656., doi:10.1159/000295249. [CrossRef] [Google Scholar]
  28. Cheng KW, Agarwal R, Mitra S, et al. Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO Mol Med. 2012;4(2):125-141. doi:10.1002/emmm.201100193 [Google Scholar]
  29. Ma, Y.f., et al. “Expression of Ras-Related Protein 25 Predicts Chemotherapy Resistance and Prognosis in Advanced Non-Small Cell Lung Cancer.” Genetics and Molecular Research, vol. 14, no. 4, 2015, pp. 13998–14008., doi: 10.4238/2015.october.29.19. [CrossRef] [Google Scholar]
  30. Fan Y, Xu BH, Yuan P, Ma F, Wang JY, Ding XY, Zhang P, Li Q, Cai RG. Docetaxel-cisplatin might be superior to docetaxel-capecitabine in the first-line treatment of metastatic triple-negative breast cancer. Ann Oncol. 2013; 24:1219–25. [CrossRef] [PubMed] [Google Scholar]
  31. Temel, S.G., Giray, A., Karakas, B. et al. RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells. Apoptosis (2020). [Google Scholar]
  32. Tong, M., et al. “Rab25 Is a Tumor Suppressor Gene with Antiangiogenic and Anti-Invasive Activities in Esophageal Squamous Cell Carcinoma.” Cancer Research, vol. 72, no. 22, 2012, pp. 6024–6035., doi: 10.1158/0008-5472.can-12-1269. [CrossRef] [PubMed] [Google Scholar]
  33. Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, et al. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest. 2010; 120:840–9. [CrossRef] [PubMed] [Google Scholar]
  34. Amornphimoltham P., et al. “Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer.” Clinical Cancer Research, vol. 19, no. 6, 2013, pp. 1375–1388., doi: 10.1158/1078-0432.ccr-12-2858. [CrossRef] [Google Scholar]
  35. Cheng, J., Volk, L., Janaki, D. K., Vyakaranam, S., Ran, S., & Rao, K. A. (2010). Tumor suppressor function of Rab25 in triple-negative breast cancer. International Journal of Cancer. doi:10.1002/ijc.24900 [Google Scholar]
  36. Luen Tang, B. Is Rab25 a tumor promoter or suppressor—context dependency on RCP status?. Tumor Biol. 31, 359–361 (2010). [CrossRef] [Google Scholar]
  37. Dozynkiewicz MA, Jamieson NB, Macpherson I, Grindlay J, van den Berghe PV, von Thun A, Morton JP, Gourley C, Timpson P, Nixon C, McKay CJ, Carter R, Strachan D, et al. Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell. 2012; 22:131–45. [CrossRef] [PubMed] [Google Scholar]
  38. Agarwal R, Jurisica I, Mills GB, Cheng KW. The emerging role of the RAB25 small GTPase in cancer. Traffic. 2009; 10:1561–8. [CrossRef] [PubMed] [Google Scholar]
  39. Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell. 2007; 13:496–510. [CrossRef] [PubMed] [Google Scholar]

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