E3S Web Conf.
Volume 78, 20192018 International Seminar on Food Safety and Environmental Engineering (FSEE 2018)
|Number of page(s)||6|
|Section||Nutrition and Health, Medical Treatment and Biomedical Engineering|
|Published online||15 January 2019|
Research Progresses of the Mechanism of Insulin Resistance in Type II Diabetes
Biotechnology, Department of Biochemistry and Biotechnology, Xiamen University, 4221-120 Xiang’an South Road, Xiamen, China
* Corresponding author: firstname.lastname@example.org
Insulin resistance(IR) is the most primary pathological mechanism of type II diabetes, a metabolic disorder characterized by chronic hyperglycemia. Insulin transduction pathways have significant effects on IR, and they are mainly classified into two pathways: insulin receptor substrate-1 (IRS- 1)/phosphatidyl inositol 3 kinase (PI3K)/protein kinase (PKB) pathway and Ras/Raf/mitogen-activated protein kinase (MAPK) pathway. Resulted from various reasons such as obesity, oxidative stress and endoplasmic reticulum(ER) stress, if any site in the pathway is abnormal, IR will be caused. Therapies to IR is to enhance insulin sensitization, including adiponectin, endolipid and metformin. We review the mechanisms of IR in type II diabetes.
© The Authors, published by EDP Sciences, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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