E3S Web Conf.
Volume 151, 2020The 1st International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2019)
|Number of page(s)||3|
|Published online||14 February 2020|
Anti-inflammatory Activity of Ethanol Extract from Malacca Leaves (Phyllanthus emblica) in Carrageenan Induced Male Mice
Clinical Laboratory Veterinary Medicine Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
2 Farmacology Laboratory Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
3 Patology Laboratory Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
4 Veterinary Study Program, Faculty of Veterinary Medicine Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
* Corresponding author: firstname.lastname@example.org
The purpose of this study was to determine the effect of the ethanol extract of malacca leaves (Phyllanthus emblica) to reduce carrageenan-induced edema in mice. This study used 25 mice which were divided into 5 groups with 5 mice per group. All the mice were induced inflammation using carrageenan at a dose of 1%. Mice in group 1 were not given piroxicam and malacca leaves extract. Mice in group 2 were treated with 20 mg of piroxicam suspension. Mice in groups 3, 4, and 5 were given ethanol extract of malacca leaves with doses of 100 mg/kg bb, 200 mg/kg bb, and 300 mg/kg bb, respectively. Edema volume measurements were performed on 5th day by collecting exudates using a syringe. Data were analyzed using one-way analysis of variance and continued with the Duncan test. The result showed that the average of edema volume in the negative control group was 0.09 ± 0.02 mL, while in the positive control group was 0.05 ± 0.03 mL. The average edema volume in groups 3, 4, dan 5 were 0.07 ± 0.01 mL, 0.06 ± 0.02 mL dan 0.07 ± 0.01 mL, respectively. It is concluded that the ethanol extract of malacca leaves (Phyllanthus emblica) can reduce the carrageenan-induced edema in male mice.
Key words: malacca leaves / carrageenan / ethanol / anti-inflammatory
© The Authors, published by EDP Sciences, 2020
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