| Issue |
E3S Web Conf.
Volume 176, 2020
International Scientific and Practical Conference “From Inertia to Develop: Research and Innovation Support to Agriculture” (IDSISA 2020)
|
|
|---|---|---|
| Article Number | 01006 | |
| Number of page(s) | 4 | |
| Section | Scientific Support for the Innovative Development of Animal Husbandry and Biotechnology | |
| DOI | https://doi.org/10.1051/e3sconf/202017601006 | |
| Published online | 22 June 2020 | |
Gene editing CRISPR/Cas9 system for producing cows with hypoallergenic milk on the background of a beta-lactoglobulin gene knockout
1 Core Facility “Genome editing”, Institute of Gene Biology of the Russian Academy of Sciences, 34/5, 119334, Vavilova str., Moscow, Russia
2 Ural Federal Agricultural Scientific Research Center of Ural Department of Russian Academy of Sciences, 620142, Belinskogo,112 A, Ekaterinburg, Russia
3 Kuban State Agrarian University, 350044, KalininaSt., 13, Krasnodar, Russia
* Correspondingauthor: silaeva@genebiology.ru
Beta-lactoglobulin is the main allergen of cow’s milk. Modern approaches to reducing the allergenicity of milk require significant costs for its fermentation. An alternative approach could be the creation of productive breeds with a knockout for the gene of this protein. This will allow, at no additional cost, to increase its safety for children who are breast-fed. In this article, we report on the development of a system for gene editing to create cows with a knockout of the beta-lactoglobulin gene.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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