Antibacterial and antioxidant activities of ethanol extract of sukun (Artocarpus altilis.) leaves against Pseudomonas aeruginosa

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No.5, Medan, 20155, Sumatera Utara, Indonesia

^* Corresponding author: edeluxputra19@gmail.com

Abstract

Antioxidants are thought to help the body fight Reactive Oxygen Species (ROS). Antioxidants are defined as “any substance that significantly slows or inhibits oxidation when present in trace amounts relative to an oxidizable substrate.” Antimicrobials generated from plants have been used to treat infectious diseases for millennia. Many investigations have been done on the antibacterial effects of herbal plant extracts., including roots, stems, leaves, and flowers. Artocarpus altilis is a versatile tree plant that is a rich source of calcium, phosphorus, carbohydrates, minerals, and vitamins. Various parts of breadfruit are used as food, cosmetic medicine, clothing, treating diarrhea, high blood pressure, and asthma. This study obtained about determine biological activities of Artocarpus altilis Leaves. The extract was prepared using water with the soxhletation method. The antibacterial activity was determined with minimun inhibitor concentration method with concentration 300-25 mg/mL can inhibit the growth of Pseudomonas aeruginosa, The MIC is the lowest concentration that may stop bacterial growth, and the number of bacteria is 10 colonies. 60.13 0.54 ppm antioxidant activity, fenol (224.67 mg GAE/g) and flavonoids (27.63 mg QE/g). The results show that Artocarpus altilis leaf ethanol extract is antibacterial and antioxidant.