Antibacterial and antioxidant activities of ethanol extract of Artocarpus lacucha Buch-Ham. leaves against Propionibacterium acne

¹ Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No.5, Kampus USU, Medan, 20155, Sumatera Utara, Indonesia
² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No.5, Kampus USU, Medan, 20155, Sumatera Utara, Indonesia

^* Corresponding author: mahatir.muhammad@usu.ac.id

Abstract

Antioxidants can neutralize free radicals that can affect biological systems in the body that can cause degenerative diseases. Antibacterial active molecules have been identified from plants, and these chemicals are being utilized to develop new and promising treatments. The Mobe plant (Artocarpus lacucha Buch-Ham.) is a species of Artocarpus member of the Moraceae family. Includes a high proportion of phenolic compounds (flavonoids and phenolic acid). This research obtained to know about the biological activity of Artocarpus lacucha Buch-Ham and their total flavonoid and total phenolic content. The extract was prepared using the soxhletation technique using ethanol as the solvent. Antibacterial activity was determined using minimum inhibitor concentration. Propionibacterium acne can be inhibited at concentrations ranging from 300 ppm to 25 ppm. The DPPH technique was used to assess antioxidant activity. The samples’ total flavonoid and phenolic content were measured colorimetrically. The DPPH test revealed an antioxidant activity of 23.33 g/mL, which was used to compute the IC50. The extract’s total phenolic (117.44 mg GAE/g) and flavonoid (3.54 mg QE/g) content were determined to be high.