| Issue |
E3S Web Conf.
Volume 251, 2021
2021 International Conference on Tourism, Economy and Environmental Sustainability (TEES 2021)
|
|
|---|---|---|
| Article Number | 02060 | |
| Number of page(s) | 11 | |
| Section | Environmental Ecological Analysis and Sustainable Development Research | |
| DOI | https://doi.org/10.1051/e3sconf/202125102060 | |
| Published online | 15 April 2021 | |
A Network Pharmacology Approach to Investigate the Underlying Mechanisms of Alpinia Katsumadai Hayata on Acne Vulgaris
1 College of Pharmacy, Guangdong Lingnan Institute of Technology, Guangzhou 510663, China
2 School of Pharmaceutical Engineering, Guangdong Food and Drug Vocational College, Guangzhou 510520, China
3 Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458, China
* The Co-first Author: Huifang Chen - College of Pharmacy, Guangdong Lingnan Institute of Technology, Guangzhou 510663, China; Email: chenhf_1968@163.com
Author Contributions *Li Wang and Huifang Chen contribute equally.
The Alpinia katsumadai Hayata Doukou, DK, is a traditional Chinese medicine that has shown superior anti-inflammatory property, which is widely used in the food and commodity industry. A network pharmacology analysis was performed to identify the potential anti-acne compounds, hub therapeutic targets, and the key pathways via TCMSP, BATMAN, CTD, PDB and PubChem databases. Finally, the “compoundtarget- pathway” network was constructed. The study found total 7 active compounds, including quercetin, (2R)-5,7-dihydroxy-2-phenylchroman-4-one, dehydrodiisoeugenol, (2R)-7-hydroxy-5-methoxy-2- phenylchroman-4-one, Pinocembrin, and 1,7-diphenyl-5-hydroxy-6-hepten-3-one alpinolide peroxide. In addition, 30 therapeutic targets, and 4 hub therapeutic targets of the DK were identified. The biological processes were primarily related to inflammatory response, response to oxidative stress, regulation of insulin secretion, etc. Which was significantly associated with ten pathways including the PI3K-Akt signaling pathways, VEGF signaling pathways, etc. Furtherly, the 4 hub targets AKT1, F2, AR, and PTGS2 with higher connectivity in PPI network were verificated though molecular docking, which once again proved that these targets are potential targets of their corresponding chemical molecules. Therefore, DK might have a synergistic effect on the anti-inflammatory effects via the various active compositions, targets and signaling pathways.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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