E3S Web Conf.
Volume 308, 20212021 6th International Conference on Materials Science, Energy Technology and Environmental Engineering (MSETEE 2021)
|Number of page(s)||7|
|Section||Environmental Ecology and Biochemical Testing|
|Published online||27 September 2021|
Pathogenesis of Alzheimer’s disease and its treatments: A systematic review
1 College of Letters and Science, University of California Davis, Davis, CA 95618, United States
2 College of Electrical, Energy and Power Engineering, Yangzhou University, Yangzhou, Jiangsu, 225127, China
3 School of construction machinery, Chang’an University, Xi’an, Shanxi, 710018, China
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by loss of memory and cognition. In this review article, three main pathogenesis of AD were described: Amyloid-beta hypothesis, Tau protein hyperphosphorylation and Neurotransmitter decrease hypothesis. Specifically, amyloid-beta accumulation can be detrimental for nervous system for Amyloid-beta hypothesis, while Tau protein hyperphosphorylation can cause the breakdown of nerve cells. With regard to Neurotransmitter decrease hypothesis, it is deemed as the direct reason to cause Alzheimer’s disease. On top of that, mainstream treatments therapy and their features, advantages and disadvantages are discussed. Firstly, medicine treatments corresponding to its pathogenesis are introduced. Secondly, gene therapy is also demonstrated which alleviates Alzheimer’s disease be means of gene modification, inactivation and immune regulation. Finally, the stem cells therapy is also described as well as other therapies. Based on our analysis, combined therapy should be put into practice to achieve a better effect. Moreover, more knowledge about AD pathogenesis is required for researchers, which provides theoretical basis and reference for treatments. These results shed light for future research of AD.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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