Hypoglycaemic effect of Bawang Dayak extracts (Eleutherine palmifolia (L.) Merr.) on Sprague Dawley rats

¹ Department of Food Quality Assurance Supervisor, College of Vocational Studies, IPB University, Indonesia
² Department of Food Science and Technology, Faculty of Agricultural Technology, IPB University, Indonesia
³ Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, IPB University, Indonesia

^* Corresponding author: earlyfebrinda@apps.ipb.ac.id

Abstract

The Dayak tribe in Kalimantan has long used bawang dayak as a traditional cure for various degenerative diseases. Previous research showed that bawang dayak bulb has an active compound that can inhibit the enzyme alpha-glucosidase, known as alpha-glucosidase inhibitor (AGI). Compounds that have such ability has a potential in controlling blood glucose level in diabetes mellitus. This research aims to study the effective dosage of aqueous extract and ethanolic extract of bawang dayak bulb as an AGI through an oral glucose tolerance test in male Sprague Dawley rats. Experimental rats were divided into 14 groups, 7 for the ethanolic extract test and 7 for the aqueous extract test. The extracts were applied in 5 dosage levels in each test, with acarbose as a drug control and distilled water as a positive control. Data were plotted to determine the area under the curve (AUC). The effective dosage was the lowest dosage that gave a significantly smaller AUC value than the AUC value of the positive control group. The effective dosage for bawang dayak aqueous extract and bawang dayak ethanolic extract was 200 mg/kg and 100 mg/kg, respectively.