Of rats and rocks: using pre-clinical PET imaging facilities in core analysis

¹ Dept. of Physics and Technology, University of Bergen, Norway
² Center for Nuclear Medicine PET, Department of Radiology, Haukeland University Hospital, Norway
³ Department of Radiology, Haukeland University Hospital, Norway
⁴ Molecular Imaging Center, Department of Biomedicine, University of Bergen, Norway

Abstract

Positron emission tomography (PET) is routinely used for medical imaging; a current surge in published geoscientific research utilizing this modality also infer increasing interest for in-situ PET imaging in core analysis. Excellent signal to noise ratio coupled with high temporal and spatial resolution suggest that PET might become the new method-of-choice for core analysis. Obstacles related to production, transfer and handling of radioactive fluids and gases must, however, be dealt with for PET to become a widely used core scale imaging technique. This paper describes an ongoing, true multidisciplinary collaboration, where pre-clinical PET imaging facilities are routinely used in core analysis to investigate dynamic fluid flow at high pressure conditions. We detail challenges and opportunities related to porous media research in established pre-clinical laboratory facilities designed for small-animal imaging, and demonstrate the significant potential of PET imaging in core scale analysis in a context related to long-term porous media carbon storage.

Explicit imaging of several fluid phases is possible by PET imaging using a range of readily available radiotracers. Relevant radiotracers to carbon storage in porous media are e.g. the carbon radioisotope ¹¹C and water-soluble tracer ¹⁸F. These are both short-lived tracers (20 - 110 min) and must be used in high doses of radiation, which present challenges related to safe transfer and handling. Although there are several obstacles to conduct advanced core analysis in hospital imaging facilities (some of which are detailed in this paper), significant advantages include trained personnel on-site to operate a local cyclotron, procedures in place to ensure safe and efficient transfer of short-lived radiopharmaceuticals from the cyclotron, and advanced image analysis capabilities available. Cyclotrons are widely available worldwide (currently more than 1200 operating cyclotrons), often located in close proximity to medical and pre-clinical imaging facilities and academic institutions. Similar collaborations may therefore also be possible elsewhere, reducing the need for allocated geophysical PET-scanners and lowering the threshold for routinely using PET imaging in core analysis.