| Issue |
E3S Web Conf.
Volume 577, 2024
4th International Conference on Applied Sciences (ICAS 2024) “Multidisciplinary Research Collaboration for Environmental, Social, and Governance (ESG) Issues”
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|---|---|---|
| Article Number | 02008 | |
| Number of page(s) | 11 | |
| Section | Social, Economies, Health, and Management Issues | |
| DOI | https://doi.org/10.1051/e3sconf/202457702008 | |
| Published online | 11 October 2024 | |
Investigating Sandoricum koetjape leaf extracts for tyrosinase inhibition: Flavonoid profiles and mechanisms
1 Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
2 Department of Chemistry, Faculty of Sciences, Universitas Negeri Malang, Kota Malang 65145, East Java, Indonesia
3 Research Centre for Pharmaceutical Ingredients and Traditional Medicines, National Research, and Innovation Agency (BRIN), Kawasan PUSPIPTEK Serpong 15314, Tangerang Selatan, Indonesia
4 Research Center for Plant Conservation, Botanic Gardens, and Forestry, BRIN, Kota Bogor 16122, Jawa Barat, Indonesia
5 Department Of Biology, College of Science, University of Bahrain, Sakhir 1017, Kingdom of Bahrain.
* Corresponding author: tjan002@brin.go.id
This study investigates the potential of flavonoid compounds from Sandoricum koetjape leaf extracts as tyrosinase inhibitors, using in vitro and in silico methodologies. Tyrosinase is crucial for melanin synthesis, and its excessive activity leads to hyperpigmentation disorders. The extracts underwent maceration, partitioning, and concentration, followed by tyrosinase inhibition assays and LC-MS/MS analysis. The ethyl acetate fraction showed the highest inhibitory activity, revealing key flavonoids like Kaempferol-3-O-β-Dglucopyranoside and Quercimeritrin. Molecular docking and dynamic simulations provided insights into their binding mechanisms. Kaempferol-3-Oβ-D-glucopyranoside exhibited a binding affinity of -8.4 kcal/mol, while Quercimeritrin had -7.7 kcal/mol. PreADME profiles indicated Quercimeritrin’s higher solubility, better skin permeability, and lower environmental toxicity. This comprehensive evaluation underscores the viability of S. koetjape as a natural source for tyrosinase inhibitors, highlighting the need for further optimization and in vivo studies to confirm efficacy and safety for dermatological applications.
© The Authors, published by EDP Sciences, 2024
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