A preliminary study on the synthetic lethal effect of berberine and olaparib on pancreatic cancer cells and its mechanism

Chengyong Zhang; Tingting Yang; Xiaoting Chen; Jiexuan Xu; Danlu Liang; Huairu Yi; Size Chen; Lanlan Huang; Naihua Liu; Shaoqiang Lin

doi:10.1051/e3sconf/202123302023

All issues

Volume 233 (2021)

E3S Web Conf., 233 (2021) 02023

References

Open Access

Issue		E3S Web Conf. Volume 233, 2021 2020 2^nd International Academic Exchange Conference on Science and Technology Innovation (IAECST 2020)


Article Number		02023
Number of page(s)		4
Section		BFS2020-Biotechnology and Food Science
DOI		https://doi.org/10.1051/e3sconf/202123302023
Published online		27 January 2021

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Chen Chunqiu, et al.“Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications..” The American journal of Chinese medicine 42.5(2014). [PubMed] [Google Scholar]
Jing Wang, et al.“Radiosensitization effects of Berberine on human breast cancer cells.” International Journal of Molecular Medicine 30.5(2012). [Google Scholar]
Qiao Liu, et al.“Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51..” PLoS ONE 6.8(2017). [Google Scholar]
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[1] Sung Yong Han, et al.“First-line chemotherapy in very elderly patients with metastatic pancreatic cancer: Gemcitabine monotherapy vs combination chemotherapy.” World Journal of Clinical Cases 8.18(2020). [Google Scholar]

[2] Dréan Amy, et al.“PARP inhibitor combination therapy..” Critical reviews in oncology/hematology 108.(2016). [PubMed] [Google Scholar]

[3] Plummer Elizabeth Ruth, ,and Calvert Hilary.“Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.” Clinical cancer research : an official journal of the American Association for Cancer Research 13.21(2007). [Google Scholar]

[4] Melisi Davide, et al.“Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity..” Clinical cancer research : an official journal of the American Association for Cancer Research 15.20(2009). [PubMed] [Google Scholar]

[5] Richard Tuli, et al.“Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (AD P-ribose) Polymerase Inhibition with ABT-888.” Tr anslational Oncology 7.3(2014). [Google Scholar]

[6] Dietmar A Jacob, et al.“Combination therapy of pol y (ADP‐ribose) polymerase inhibitor 3‐aminoben zamide and gemcitabine shows strong antitumor acti vity in pancreatic cancer cells.” Journal of Gastroent erology and Hepatology 22.5(2007). [Google Scholar]

[7] Chen Chunqiu, et al.“Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications..” The American journal of Chinese medicine 42.5(2014). [PubMed] [Google Scholar]

[8] Jing Wang, et al.“Radiosensitization effects of Berberine on human breast cancer cells.” International Journal of Molecular Medicine 30.5(2012). [Google Scholar]

[9] Qiao Liu, et al.“Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51..” PLoS ONE 6.8(2017). [Google Scholar]

[10] Dong Hou, et al.“Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition.” Cell Death & Disease 8.10(2017). [PubMed] [Google Scholar]